The Role of Platelet Rich Fibrin for Closure of Oronasal Fistula Post Palatoplasty through Abilities to Keep Growth Factor Activity for a Relatively Longer Period and Stimulate Tissue Regeneration Effectively

Oronasal fistula is one of the unfortunate consequences cleft palate surgery. This can be done after surgery in patients with palate, defined as an abnormal connection between oral and nasal cavities. Multiple systems have attempted that classification. It a small, symptomatic or asymptomatic needs correction. Its speed varies greatly depending on many factors. Both surgical non-surgical methods (the advantages disadvantages each should considered) are available for correction, there combination therapies help improve outcomes. Platelet-rich fibrin (PRF) novel Generation platelet concentrate, very easy to prepare handle without use biochemicals. production dependent accumulation platelets release cytokines growth Enriched factors, this hemostatic plug operate. Adapted soft hard tissue healing. used various fields dentistry, especially maxillofacial Reports role PRF repairing oronasal closure sparse literature, relation other flaps.